The Role of CD 34 Hematopoietic Progenitor Cells, Macrophages, and Smooth Muscle Cells in Human Coronary Artery Atherogenesis
نویسندگان
چکیده
منابع مشابه
Role of Interleukin - l 5 in the Development of Human CD 56 ' Natural Killer Cells From CD 34 + Hematopoietic Progenitor Cells
Human natural killer INK) cells are bone marrow (BM)-derived CD2+CD16+CD56+ large granular lymphocytes (LGL) that lack CD3 yet contain the T-cell receptor (-chain (c-TCR). NK cells provide requisite interferon-y (IFN-y) during the early stages of infection in several experimental animal models. A number of studies have shown that human CD3-CD56' NK cells can be obtained from BM-derived CD34+ he...
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The human Lin2CD342 cell population contains a newly defined class of hematopoietic stem cells that reconstitute hematopoiesis in xenogeneic transplantation systems. We therefore developed a culture condition in which these cells were maintained and then acquired CD34 expression and the ability to produce colony-forming cells (CFC) and SCIDrepopulating cells (SRCs). A murine bone marrow stromal...
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Background and purpose: Human pluripotent stem cells (hPSCs) with the ability to differentiate into adult cells have provided a new perspective for treatment of some diseases. But, the efficiency of differentiation methods to generate hematopoietic progenitor cells (HPCs) is faced with multiple challenges. In the present study, we investigated the formation of hemato-endothelial-like structure...
متن کاملSmooth muscle progenitor cells in human blood.
BACKGROUND Recent animal data suggest that vascular smooth muscle cells within the neointima of the vessel wall may originate from bone marrow, providing indirect evidence for circulating smooth muscle progenitor cells (SPCs). Evidence for circulating SPCs in human subjects does not exist, and the mechanism whereby such putative SPCs may home to sites of plaque formation is presently not unders...
متن کاملDNA methylation, smooth muscle cells, and atherogenesis.
DNA methylation is a form of epigenetic modification of the genome that can regulate gene expression. Hypermethylation of CpG islands in the promoter areas leads to decreased gene expression, whereas promoters of actively transcribed genes remain nonmethylated. Because of cellular proliferation and monoclonality of at least some of the lesion cells, atherosclerotic lesions have been compared wi...
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ژورنال
عنوان ژورنال: Open Access Macedonian Journal of Medical Sciences
سال: 2020
ISSN: 1857-9655
DOI: 10.3889/oamjms.2020.4978